Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920861 | 0.89 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2HPGDMAPK14 | |
| SCHEMBL24920722 | 0.86 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24920745 | 0.82 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24920742 | 0.82 | SMO (0.38) | NPC1RAB9ASMN1; SMN2HPGDMAPK14 | |
| SCHEMBL24920733 | 0.81 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24920723 | 0.80 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24920736 | 0.80 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24920749 | 0.80 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL24921653 | 0.80 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HPGDMAPK14 | |
| SCHEMBL24920735 | 0.80 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |