Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489922 | 0.89 | CHRM1 (0.51) | CHRM1MAPTTP53RXFP1SMN1; SMN2 | |
| SCHEMBL2487940 | 0.84 | CHRM1 (0.44) | CHRM1MAPTTP53RXFP1NPC1 | |
| SCHEMBL2486150 | 0.83 | MAPT (0.41) | CHRM1MAPTTP53RXFP1PTGDR2 | |
| SCHEMBL2485714 | 0.81 | CHRM1 (0.45) | CHRM1MAPTTP53RXFP1NPC1 | |
| SCHEMBL2489082 | 0.80 | CHRM1 (0.45) | CHRM1MAPTTP53RXFP1SMN1; SMN2 | |
| SCHEMBL2488401 | 0.80 | CHRM1 (0.62) | CHRM1 | |
| SCHEMBL2490966 | 0.80 | CHRM1 (0.42) | CHRM1MAPTTP53RXFP1SMN1; SMN2 | |
| SCHEMBL2487937 | 0.78 | CHRM1 (0.42) | CHRM1MAPTTP53RXFP1NPC1 | |
| SCHEMBL2488682 | 0.72 | CHRM1 (0.57) | CHRM1MAPTTP53RXFP1PTGDR2 | |
| SCHEMBL2486148 | 0.71 | CHRM1 (0.52) | CHRM1MAPTTP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |