Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233811 | 0.89 | CHRM1 (0.47) | CHRM1MAPTTP53RXFP1PTGDR2 | |
| SCHEMBL2488912 | 0.88 | ROCK2 (0.46) | CHRM1 | |
| SCHEMBL2487940 | 0.88 | CHRM1 (0.44) | CHRM1MAPTTP53RXFP1NPC1 | |
| SCHEMBL2489039 | 0.87 | CHRM1 (0.74) | CHRM1MAPTTP53TOP1 | |
| SCHEMBL2487142 | 0.87 | CHRM1 (0.48) | CHRM1MAPTCHRM5 | |
| SCHEMBL2486084 | 0.87 | CHRM1 (0.53) | CHRM1MAPTBDKRB1TP53RXFP1 | |
| SCHEMBL2488647 | 0.86 | CHRM1 (0.76) | CHRM1MAPTNPC1RAB9ANOD2 | |
| SCHEMBL2486645 | 0.86 | CHRM1 (0.42) | CHRM1BDKRB1 | |
| SCHEMBL2489435 | 0.84 | CHRM1 (0.43) | CHRM1MAPTBDKRB1TP53RXFP1 | |
| SCHEMBL2485728 | 0.84 | CHRM1 (0.47) | CHRM1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |