Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.40 |
| ▸ | HNF4A | P41235 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246576 | 0.90 | HTT (0.46) | CDC25BHTTKDM4ELMNAALDH1A1 | |
| SCHEMBL1487894 | 0.83 | KDM4C (0.42) | KDM4EOXTRALDH1A1MAPTDHODH | |
| SCHEMBL1487890 | 0.79 | NAPRT (0.43) | CDC25BATMHTTKDM4EOXTR | |
| SCHEMBL17197587 | 0.78 | CDC25B (0.50) | CDC25BATMHTTKDM4EMCL1 | |
| SCHEMBL15309180 | 0.78 | ALDH1A1 (0.43) | HTTKDM4ELMNAALDH1A1ALOX15 | |
| SCHEMBL4022644 | 0.76 | ALDH1A1 (0.48) | CDC25BATMKDM4EMCL1ACMSD | |
| SCHEMBL2595456 | 0.75 | CDC25B (0.47) | CDC25BATMHTTKDM4EMCL1 | |
| SCHEMBL6387172 | 0.74 | ALDH1A1 (0.50) | CDC25BHTTKDM4ELMNAALDH1A1 | |
| SCHEMBL1239567 | 0.73 | PTPN1 (0.59) | CDC25BATM | |
| SCHEMBL18810823 | 0.72 | KMT2A (0.51) | ATMKDM4ELMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |