Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 14/20 | 0.65 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.57 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.54 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692039 | 1.00 | PTGER4 (0.65) | PTGER4PTGER2MRGPRX4INPPL1PTGER1 | |
| SCHEMBL690993 | 0.95 | PTGER4 (0.67) | PTGER4PTGER2MRGPRX4INPPL1PTGER1 | |
| SCHEMBL26914664 | 0.95 | PTGER4 (0.67) | PTGER4PTGER2MRGPRX4INPPL1PTGER1 | |
| SCHEMBL691910 | 0.94 | PTGER4 (0.74) | PTGER4PTGER2MRGPRX4PTGER1PTGDR | |
| SCHEMBL4174040 | 0.94 | PTGER4 (0.74) | PTGER4PTGER2MRGPRX4PTGER1PTGDR | |
| SCHEMBL692208 | 0.91 | PTGER4 (0.64) | PTGER4PTGER2MRGPRX4PTGER1PTGDR | |
| SCHEMBL691609 | 0.91 | PTGER4 (0.70) | PTGER4PTGER2PTGER1PTGDR | |
| SCHEMBL4019942 | 0.91 | PTGER4 (0.53) | PTGER4PTGER2MRGPRX4INPPL1PTGER1 | |
| SCHEMBL692475 | 0.90 | PTGER4 (0.68) | PTGER4PTGER2MRGPRX4PTGER1PTGDR | |
| SCHEMBL4014640 | 0.87 | PTGER4 (0.72) | PTGER4PTGER2MRGPRX4PTGER1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102209710-A | Pyrrolidines | PFIZER LTD | 2011-10-05 | — | — | CN | disclosed |
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | disclosed |
| EP-2222665-A1 | AZETIDINES AS EP2 ANTAGONISTS | Pfizer Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | disclosed |
| EP-2155666-A1 | AZETIDINE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | Pfizer Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2009063365-A1 | AZETIDINES AS EP2 ANTAGONISTS | PFIZER LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |
| WO-2008139287-A1 | AZETIDINE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN E2 ANTAGONISTS | PFIZER LIMITED (GB) | 2008-11-20 | — | — | WO | disclosed |