Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792144 | 0.83 | ADORA2A (0.48) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL29539989 | 0.83 | CYP2A6 (0.57) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL23336394 | 0.83 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL28118705 | 0.81 | ADORA1 (0.74) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL14127720 | 0.81 | ADORA1 (0.61) | ADORA2AADORA1LMNA | |
| SCHEMBL6832429 | 0.79 | ADORA1 (0.61) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL30402022 | 0.79 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL6831577 | 0.77 | MEN1 (0.59) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL19055026 | 0.76 | CYP2A6 (0.53) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 | |
| SCHEMBL28006788 | 0.76 | CYP2A6 (0.50) | HSP90AA1HSP90AB1PTK2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030487-B2 | 2-amino—5-substituted pyrimidine inhibitors | TARGEGEN, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | KDR, FLT4, FLT1 | HSP90AA1 2819/4885HSP90AB1 2637/4885PTK2 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.