Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490301 | 1.00 | CTSC (0.33) | CTSC | |
| SCHEMBL2492567 | 1.00 | CTSC (0.33) | CTSC | |
| SCHEMBL2490298 | 1.00 | CTSC (0.33) | CTSC | |
| Hydrochloric Acid SCHEMBL2491288 | 0.92 | CTSC (0.33) | CTSC | |
| Hydrochloric Acid SCHEMBL2491286 | 0.92 | CTSC (0.33) | CTSC | |
| SCHEMBL14802193 | 0.90 | CTSC (0.34) | CTSC | |
| SCHEMBL14802188 | 0.89 | DPP4 (0.33) | CTSC | |
| SCHEMBL2490743 | 0.86 | CTSC (0.35) | CTSC | |
| SCHEMBL2492932 | 0.86 | CTSC (0.35) | CTSC | |
| SCHEMBL2490741 | 0.86 | CTSC (0.35) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370800-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2022-06-28 | — | — | US | disclosed |
| US-11370800-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2022-06-28 | — | — | US | disclosed |
| EP-3580205-B1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2021-05-05 | — | — | EP | disclosed |
| EP-3580205-B1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2021-05-05 | — | — | EP | disclosed |
| US-20200377521-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-12-03 | — | — | US | disclosed |
| US-20200377521-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-12-03 | — | — | US | disclosed |
| US-10836778-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2020-11-17 | — | — | US | disclosed |
| US-10836778-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2020-11-17 | — | — | US | disclosed |
| US-20130172362-A1 | Imidazothiazole Derivatives Having Proline Ring Structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
| US-20130172362-A1 | Imidazothiazole Derivatives Having Proline Ring Structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
| US-20130172362-A1 | Imidazothiazole Derivatives Having Proline Ring Structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
| US-8404691-B2 | Imidazothiazole derivatives having proline ring structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-03-26 | — | — | US | disclosed |
| US-8404691-B2 | Imidazothiazole derivatives having proline ring structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-03-26 | — | — | US | disclosed |
| US-8404691-B2 | Imidazothiazole derivatives having proline ring structure | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-03-26 | — | — | US | disclosed |
| EP-2380892-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE | Daiichi Sankyo Company, Limited (JP) | 2011-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172362-A1 | Imidazothiazole Derivatives Having Proline Ring Structure | MDM2, TP53, TP53BP1 | CTSC 1390/4885 |
| US-10836778-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | DHPS, DUS2, RPS2 | CTSC 897/4885 |
| US-11370800-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | DHPS, DUS2, RPS2 | CTSC 897/4885 |
| US-20200377521-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | DHPS, DUS2, RPS2 | CTSC 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.