Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577126 | 0.88 | ALDH1A1 (0.68) | CYP2C19ALDH1A1NPSR1SMN1; SMN2KEAP1 | |
| SCHEMBL13630623 | 0.81 | CYP2C19 (0.59) | CYP2C19ALDH1A1NPSR1TSHRSMN1; SMN2 | |
| SCHEMBL9281374 | 0.80 | CYP2C19 (0.67) | CYP2C19ALDH1A1NPSR1SMN1; SMN2KEAP1 | |
| SCHEMBL18221865 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TSHRSMN1; SMN2LMNACA12 | |
| SCHEMBL18221898 | 0.79 | CA12 (0.60) | ALDH1A1CA12CA9CYP1A2CYP3A4 | |
| SCHEMBL28670237 | 0.78 | CYP2C19 (0.55) | CYP2C19ALDH1A1NPSR1TSHRSMN1; SMN2 | |
| SCHEMBL10460023 | 0.77 | CYP2C19 (0.68) | CYP2C19ALDH1A1NPSR1SMN1; SMN2KEAP1 | |
| SCHEMBL11890046 | 0.77 | CYP2C19 (0.73) | CYP2C19ALDH1A1NPSR1SMN1; SMN2KEAP1 | |
| SCHEMBL18221875 | 0.77 | CA12 (0.57) | ALDH1A1SMN1; SMN2LMNACA12CA9 | |
| Hydrochloric Acid SCHEMBL15621007 | 0.76 | CYP2C19 (0.66) | CYP2C19ALDH1A1NPSR1SMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230031954-A1 | TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT | TETRAPHASE PHARMACEUTICALS, INC. | 2023-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230031954-A1 | TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT | MCL1, ABL1, MALT1 | CYP2C19 3708/4885ALDH1A1 3787/4885NPSR1 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.