Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5427853 | 1.00 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL5427850 | 1.00 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL489823 | 0.95 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL15855803 | 0.89 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL2495912 | 0.89 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL1257155 | 0.87 | HSD17B10 (0.49) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL5328715 | 0.87 | HSD17B10 (0.49) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL1250737 | 0.87 | HSD17B10 (0.49) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL31048243 | 0.86 | HSD17B10 (0.48) | HSD17B10SMN1; SMN2NPC1USP30LMNA | |
| SCHEMBL4995909 | 0.85 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2NPC1USP30LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| EP-1296976-B1 | NOVEL 1,3-DIHYDRO-2H-INDOL-ONE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI AVENTIS (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1296976-A1 | NOVEL 1,3-DIHYDRO-2H-INDOL-ONE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Sanofi-Aventis (FR) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098295-A1 | NOVEL 1,3-DIHYDRO-2H-INDOL-ONE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI-SYNTHELABO (FR) | 2001-12-27 | — | — | WO | disclosed |