Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 12/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487836 | 1.00 | HCRTR2 (0.43) | HCRTR2HCRTR1ALDH1A1MAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL2532203 | 0.99 | HCRTR2 (0.43) | HCRTR2HCRTR1ALDH1A1MAPK1MEN1 | |
| SCHEMBL2489774 | 0.93 | HCRTR1 (0.43) | HCRTR2HCRTR1ALDH1A1MAPK1REN | |
| SCHEMBL2489769 | 0.93 | HCRTR1 (0.43) | HCRTR2HCRTR1ALDH1A1MAPK1REN | |
| Hydrochloric Acid SCHEMBL2512752 | 0.92 | HCRTR1 (0.42) | HCRTR2HCRTR1ALDH1A1MAPK1REN | |
| SCHEMBL2488664 | 0.85 | HCRTR1 (0.44) | HCRTR2HCRTR1ALDH1A1MAPK1MEN1 | |
| SCHEMBL2488670 | 0.85 | HCRTR1 (0.44) | HCRTR2HCRTR1ALDH1A1MAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL2512388 | 0.84 | HCRTR1 (0.43) | HCRTR2HCRTR1ALDH1A1MAPK1MEN1 | |
| SCHEMBL4167405 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL2124396 | 0.78 | PDE8B (0.41) | HCRTR2ALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379550-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010072722-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | WO | disclosed |