Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 8/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22851365 | 0.98 | EPHX1 (0.48) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL22851023 | 0.88 | EPHX1 (0.52) | EPHX1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL18525926 | 0.85 | EPHX1 (0.39) | EPHX1TSHRTHRBGGPS1ALDH1A1 | |
| SCHEMBL19352948 | 0.85 | EPHX1 (0.39) | EPHX1TSHRTHRBGGPS1ALDH1A1 | |
| SCHEMBL20643823 | 0.85 | EPHX1 (0.44) | EPHX1TSHRTHRBGGPS1ALDH1A1 | |
| SCHEMBL24045162 | 0.85 | EPHX1 (0.39) | EPHX1TSHRTHRBGGPS1ALDH1A1 | |
| SCHEMBL21790405 | 0.83 | EPHX1 (0.42) | EPHX1TSHRTHRBGGPS1ALDH1A1 | |
| SCHEMBL22414336 | 0.82 | TSHR (0.40) | EPHX1TSHRTHRBGGPS1FDPS | |
| SCHEMBL21155148 | 0.82 | TSHR (0.40) | EPHX1TSHRTHRBGGPS1FDPS | |
| SCHEMBL19242564 | 0.80 | TSHR (0.36) | EPHX1TSHRTHRBGGPS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230031954-A1 | TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT | TETRAPHASE PHARMACEUTICALS, INC. | 2023-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230031954-A1 | TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT | MCL1, ABL1, MALT1 | EPHX1 4089/4885S1PR2 3294/4885S1PR4 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.