Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16978736 | 0.80 | HSD17B10 (0.53) | HTTKMT2AMAPTMEN1KDM4E | |
| SCHEMBL20161244 | 0.78 | CYP3A4 (0.38) | HTTSMN1; SMN2GFERKMT2AMAPT | |
| SCHEMBL11175667 | 0.78 | MAPT (0.61) | HTTSMN1; SMN2LMNARAB9AGFER | |
| SCHEMBL29505194 | 0.76 | MAPT (0.49) | SMN1; SMN2LMNAKMT2AMAPTMEN1 | |
| SCHEMBL22719716 | 0.76 | MAPT (0.49) | SMN1; SMN2LMNAKMT2AMAPTMEN1 | |
| SCHEMBL1040774 | 0.76 | HDAC6 (0.68) | HTTSMN1; SMN2LMNARAB9AGFER | |
| SCHEMBL6130238 | 0.76 | IDO1 (0.56) | HTTSMN1; SMN2LMNARAB9AGFER | |
| SCHEMBL29353516 | 0.76 | HDAC6 (0.68) | HTTSMN1; SMN2LMNARAB9AGFER | |
| SCHEMBL30023202 | 0.76 | HTT (0.53) | HTTSMN1; SMN2LMNARAB9AGFER | |
| SCHEMBL7599961 | 0.75 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2LMNARAB9AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009982-A1 | SMALL MOLECULE INHIBITION OF DEUBIQUITINATING ENZYME JOSEPHIN DOMAIN CONTAINING 1 (JOSD1) AS A TARGETED THERAPY FOR LEUKEMIAS WITH MUTANT JANUS KINASE 2 (JAK2) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-02 | — | — | WO | disclosed |