Sugi Predict

Sugi Predict / Compounds / SCHEMBL22719716

SCHEMBL22719716

SCHEMBL22719716

C=Cc1cc(S(=O)(=O)NC)ccc1NCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 12/20 0.49
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ LMNA P02545 2/20 0.49
▸ ALOX15 P16050 1/20 0.44
▸ L3MBTL1 Q9Y468 3/20 0.43
▸ GAA P10253 7/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP3A4 P08684 2/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ CRHBP P24387 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ CRHR2 Q13324 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ TP53 P04637 9/20 0.42
▸ SCN1A P35498 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29505194 1.00 MAPT (0.49) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL29438869 0.81 PKM (0.53) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL22635628 0.81 PKM (0.53) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL22718247 0.78 KDM4E (0.67) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL20766286 0.77 KDM4E (0.55) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL29438895 0.77 KDM4E (0.55) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL24928429 0.76 HTT (0.49) MAPTMEN1KMT2ALMNAL3MBTL1
SCHEMBL17749347 0.72 ALOX15 (0.80) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL20779711 0.72 MAPT (0.42) MAPTMEN1KMT2ALMNAALOX15
SCHEMBL22718183 0.72 GAA (0.52) MAPTMEN1KMT2ALMNAALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11925651-B2 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-03-12 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-11458149-B1 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-10-04 — — US disclosed
CN-114502540-A TEAD inhibitors and uses thereof 医肯纳肿瘤学公司 2022-05-13 — — CN disclosed
EP-3976192-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2022-04-06 — — EP disclosed
WO-2020243423-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2020-12-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF TEAD2, TEAD3, TEAD4 MAPT 507/4885MEN1 3307/4885KMT2A 2717/4885
US-11925651-B2 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 MAPT 507/4885MEN1 3307/4885KMT2A 2717/4885
US-11458149-B1 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 MAPT 507/4885MEN1 3307/4885KMT2A 2717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.