Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845578 | 0.79 | PDE5A (0.38) | PDE4APDE4BPDE4CPDE4DMKNK1 | |
| SCHEMBL24929104 | 0.78 | FEN1 (0.38) | PDE4AMCHR1MKNK1MKNK2CSNK2A1 | |
| SCHEMBL24930069 | 0.78 | CSNK2A1 (0.39) | PDE4AMCHR1PDE4BPDE4CPDE4D | |
| SCHEMBL24928863 | 0.75 | CSNK2A1 (0.36) | MCHR1MKNK1MKNK2CSNK2A1KMO | |
| SCHEMBL12953545 | 0.70 | PDE4B (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10012300 | 0.70 | CSNK2A1 (0.45) | PDE4AMCHR1PDE4BPDE4CPDE4D | |
| SCHEMBL12952665 | 0.69 | SCN8A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12952904 | 0.69 | SCN8A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1136135 | 0.68 | NPY1R (0.50) | PDE4AMCHR1PDE4BPDE4CPDE4D | |
| SCHEMBL1135987 | 0.68 | CSNK2A1 (0.44) | PDE4AMCHR1PDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881657-A | Phenyl-sulfamoyl-benzoic acid derivatives as ERAP1 modulators | 格雷沃尔夫治疗有限公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023007188-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2023-02-02 | — | — | WO | disclosed |