SCHEMBL2492873

SCHEMBL2492873

O=C(Nc1cc(-c2ccccc2Cl)ccn1)c1ccc(Oc2cc3c(cc2Cl)CCCO3)cc1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 19/20 0.46
DEGS1 O15121 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2489027 0.89 DEGS1 (0.50) PTGDR2DEGS1
SCHEMBL2488127 0.89 PTGDR2 (0.49) PTGDR2
SCHEMBL2489612 0.89 PTGDR2 (0.48) PTGDR2
SCHEMBL2492651 0.84 PTGDR2 (0.56) PTGDR2
SCHEMBL2493195 0.83 PTGDR2 (0.45) PTGDR2
SCHEMBL2131743 0.83 PTGDR2 (0.68) PTGDR2
SCHEMBL2489660 0.82 KCNQ3 (0.44) PTGDR2
SCHEMBL17817981 0.81 PTGDR2 (0.55) PTGDR2
SCHEMBL2489819 0.80 PTGDR2 (0.50) PTGDR2DEGS1
SCHEMBL2489963 0.79 PTGDR2 (0.50) PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379535-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES Array Biopharma Inc. (US) 2011-10-26 EP disclosed