Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29259946 | 0.95 | POLB (0.43) | MAPK1MAPTPOLBPTPN1KCNQ3 | |
| SCHEMBL30361455 | 0.86 | MAPT (0.48) | MAPK1MAPTPOLBPDGFRBKDR | |
| SCHEMBL23675170 | 0.86 | MAPT (0.48) | MAPK1MAPTPOLBPDGFRBKDR | |
| SCHEMBL29259667 | 0.82 | MAPT (0.68) | MAPK1MAPTPOLBPTPN1KCNQ3 | |
| SCHEMBL30361517 | 0.82 | MAPT (0.68) | MAPK1MAPTPOLBPTPN1KCNQ3 | |
| SCHEMBL23675260 | 0.82 | MAPT (0.51) | MAPK1MAPTPOLBPDGFRBKDR | |
| SCHEMBL29996009 | 0.82 | MAPT (0.51) | MAPK1MAPTPOLBPDGFRBKDR | |
| SCHEMBL30947685 | 0.81 | HPGD (0.47) | PTPN1KCNQ3KCNQ2JAK2JAK1 | |
| SCHEMBL13202023 | 0.80 | MAPK1 (0.52) | MAPK1MAPTPOLBPDGFRBKDR | |
| SCHEMBL31717138 | 0.79 | PDGFRB (0.56) | MAPK1MAPTPOLBPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |