Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680626 | 0.89 | GRM5 (0.46) | GRM5HPGDLRRK2VNN1KDM4E | |
| SCHEMBL23675265 | 0.88 | GRM5 (0.48) | GRM5HPGDLRRK2VNN1 | |
| SCHEMBL29564740 | 0.88 | GRM5 (0.48) | GRM5HPGDLRRK2VNN1 | |
| SCHEMBL24929595 | 0.85 | GRM5 (0.46) | GRM5HPGDLRRK2 | |
| SCHEMBL24929270 | 0.83 | LRRK2 (0.45) | HPGDLRRK2THRBKDM4ENPC1 | |
| SCHEMBL28883069 | 0.78 | CRBN (0.54) | HPGDSMN1; SMN2 | |
| SCHEMBL24329653 | 0.77 | GRM5 (0.42) | GRM5HPGDLRRK2VNN1 | |
| SCHEMBL25300159 | 0.76 | GRM5 (0.60) | GRM5HPGDLRRK2KDM4E | |
| SCHEMBL30589648 | 0.76 | GRM5 (0.60) | GRM5HPGDLRRK2KDM4E | |
| SCHEMBL13202023 | 0.74 | MAPK1 (0.52) | GRM5HPGDTHRBKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201926-A | Bicyclic PGDH inhibitors and methods of making and using the same | 埃皮里姆生物股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-4377314-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |