Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30882873 | 0.66 | — | — | |
| SCHEMBL25238182 | 0.64 | — | — | |
| SCHEMBL6329631 | 0.61 | — | — | |
| SCHEMBL14131574 | 0.61 | HSD17B3 (0.38) | NOTUM | |
| SCHEMBL5969104 | 0.59 | NOTUM (0.32) | NOTUM | |
| SCHEMBL1286641 | 0.59 | NOTUM (0.31) | NOTUM | |
| SCHEMBL16795955 | 0.58 | MEN1 (0.35) | NOTUM | |
| SCHEMBL7674201 | 0.53 | — | — | |
| SCHEMBL11404095 | 0.53 | — | — | |
| SCHEMBL310712 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379513-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078408-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2010-07-08 | — | — | WO | disclosed |