⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31758285 | 0.80 | — | — | |
| SCHEMBL9391317 | 0.66 | CYP1A2 (0.30) | — | |
| SCHEMBL2492988 | 0.61 | NOTUM (0.31) | — | |
| SCHEMBL5969104 | 0.57 | NOTUM (0.32) | — | |
| SCHEMBL64071 | 0.56 | NOTUM (0.43) | — | |
| SCHEMBL1208896 | 0.56 | — | — | |
| SCHEMBL6840184 | 0.56 | — | — | |
| SCHEMBL3912317 | 0.56 | NOTUM (0.52) | — | |
| Butanedione SCHEMBL15655934 | 0.52 | TSHR (0.54) | — | |
| SCHEMBL20517758 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919357-B2 | α adrenergic agents | MOLECULAR DESIGN INTERNATIONAL INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1418907-A4 | NOVEL ALPHA ADRENERGIC AGENTS | MOLECULAR DESIGN INTERNAT INC (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1418907-A1 | NOVEL ALPHA ADRENERGIC AGENTS | Molecular Design International Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| US-20040009976-A1 | Hypoglycemic imidazoline compounds | TAKEUCHI KUMIKO (US) | 2004-01-15 | — | — | US | disclosed |
| US-20030092741-A1 | Novel alpha adrenergic agents | MOLECTULAR DESIGN INTERNATIONAL INC. | 2003-05-15 | — | — | US | disclosed |
| EP-0924209-B1 | Hypoglycemic imidazoline compounds | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2003013515-A1 | NOVEL ALPHA ADRENERGIC AGENTS | MOLECTULAR DESIGN INTERNATIONAL INC. (US) | 2003-02-20 | — | — | WO | disclosed |
| EP-1266897-A2 | Hypoglycemic imidazoline compounds | ELI LILLY AND COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6410562-B1 | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY | 2002-06-25 | — | — | US | disclosed |
| WO-1999032482-A1 | HYPOGLYCEMIC IMIDAZOLINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |
| EP-0924209-A1 | Hypoglycemic imidazoline compounds | ELI LILLY AND COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| US-4234594-A | Pyrazolyl amino imidazolines as antihypertensive agents | ABBOTT LABORATORIES (US) | 1980-11-18 | — | — | US | disclosed |
| US-4226773-A | Pyrazolyl amino imidazolines as diuretic agents | ABBOTT LABORATORIES (US) | 1980-10-07 | — | — | US | disclosed |