Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24929319 | 0.84 | HPGD (0.50) | HPGDMKNK1MKNK2SCN10AFLT3 | |
| SCHEMBL30361476 | 0.84 | HPGD (0.50) | HPGDMKNK1MKNK2SCN10AFLT3 | |
| SCHEMBL30947686 | 0.83 | HPGD (0.49) | HPGDMKNK1MKNK2FGFR3KDR | |
| SCHEMBL24929322 | 0.83 | HPGD (0.53) | HPGDMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL24929887 | 0.81 | HPGD (0.46) | HPGDMKNK1MKNK2FGFR3KDR | |
| SCHEMBL30361443 | 0.79 | HPGD (0.45) | HPGDMKNK1MKNK2FGFR3 | |
| SCHEMBL24929321 | 0.79 | HPGD (0.45) | HPGDMKNK1MKNK2FGFR3 | |
| SCHEMBL24929888 | 0.76 | HPGD (0.47) | HPGDCYP3A4ALDH1A1 | |
| SCHEMBL25342736 | 0.76 | MKNK1 (0.44) | HPGDMKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL30482612 | 0.76 | MKNK1 (0.44) | HPGDMKNK1MKNK2CYP3A4EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201926-A | Bicyclic PGDH inhibitors and methods of making and using the same | 埃皮里姆生物股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-4377314-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |