Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361476 | 0.91 | HPGD (0.50) | HPGDKDRMKNK1MKNK2AKT1 | |
| SCHEMBL24929319 | 0.91 | HPGD (0.50) | HPGDKDRMKNK1MKNK2AKT1 | |
| SCHEMBL24929887 | 0.88 | HPGD (0.46) | HPGDKDRMKNK1MKNK2AKT1 | |
| SCHEMBL24929322 | 0.84 | HPGD (0.53) | HPGDKDRMKNK1MKNK2JAK2 | |
| SCHEMBL24929889 | 0.83 | HPGD (0.48) | HPGDKDRMKNK1MKNK2FGFR3 | |
| SCHEMBL30361443 | 0.80 | HPGD (0.45) | HPGDMKNK1MKNK2VNN1FGFR3 | |
| SCHEMBL24929321 | 0.80 | HPGD (0.45) | HPGDMKNK1MKNK2VNN1FGFR3 | |
| SCHEMBL24929888 | 0.77 | HPGD (0.47) | HPGDAKT1AKT2VNN1 | |
| SCHEMBL24942616 | 0.69 | HPGD (0.50) | HPGDVNN1 | |
| SCHEMBL25342736 | 0.69 | MKNK1 (0.44) | HPGDMKNK1MKNK2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201926-A | Bicyclic PGDH inhibitors and methods of making and using the same | 埃皮里姆生物股份有限公司 | 2024-06-14 | — | — | CN | disclosed |