Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249677 | 0.83 | PIK3CD (0.36) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL3414418 | 0.81 | PIK3CD (0.39) | PIK3CDRPS6KB1MAP4K4EGFR | |
| SCHEMBL249301 | 0.81 | PIK3CD (0.39) | PIK3CDRPS6KB1MAP4K4EGFR | |
| SCHEMBL4434824 | 0.81 | LMNA (0.42) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL250361 | 0.80 | PIK3CD (0.38) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL16799113 | 0.80 | LMNA (0.39) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL249910 | 0.80 | PIK3CD (0.37) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4433351 | 0.79 | MAP4K4 (0.41) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4563263 | 0.79 | PIK3CD (0.40) | PIK3CDLMNASMN1; SMN2HSD17B10EGFR | |
| SCHEMBL4563262 | 0.79 | PIK3CD (0.40) | PIK3CDLMNASMN1; SMN2HSD17B10EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |