Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.75 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.71 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | BLK | P51451 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | STK3 | Q13188 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040958 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Hydrochloric Acid SCHEMBL29576123 | 0.85 | ROCK2 (0.98) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Hydrochloric Acid SCHEMBL15639456 | 0.85 | ROCK2 (0.98) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL17038103 | 0.84 | ROCK2 (0.81) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL15640059 | 0.83 | ROCK2 (0.80) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL18056386 | 0.83 | ROCK1 (1.00) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL17040955 | 0.82 | ROCK2 (0.78) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL17025840 | 0.82 | ROCK2 (0.78) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL22967018 | 0.81 | ROCK1 (0.71) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL24862666 | 0.81 | ROCK2 (0.76) | ROCK2ROCK1CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |