Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30896281 | 1.00 | MAPT (0.47) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL29203434 | 1.00 | MAPT (0.47) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL24933345 | 0.82 | CYP2D6 (0.50) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL24933047 | 0.82 | CYP2D6 (0.50) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL7225393 | 0.79 | LSS (0.47) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL7225391 | 0.79 | LSS (0.47) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL24933773 | 0.76 | MAPT (0.47) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL30896305 | 0.76 | MAPT (0.47) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL29203464 | 0.76 | MAPT (0.47) | MAPTMAPK1KDM4ETDP1ALDH1A1 | |
| SCHEMBL1496588 | 0.76 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |