Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225391 | 1.00 | LSS (0.47) | LSSPPARDAOC3POLBAPP | |
| SCHEMBL11802298 | 0.80 | LSS (0.47) | LSSPPARDAOC3APPALDH1A1 | |
| SCHEMBL11802292 | 0.80 | LSS (0.47) | LSSPPARDAOC3APPALDH1A1 | |
| SCHEMBL9326067 | 0.79 | AOC3 (0.64) | AOC3MEN1ALDH1A1KMT2AMAOB | |
| SCHEMBL9326064 | 0.79 | AOC3 (0.64) | AOC3MEN1ALDH1A1KMT2AMAOB | |
| SCHEMBL24933765 | 0.79 | MAPT (0.47) | POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL30896281 | 0.79 | MAPT (0.47) | POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL11267081 | 0.78 | LSS (0.44) | LSSPPARDAOC3APPALDH1A1 | |
| SCHEMBL11267037 | 0.78 | LSS (0.44) | LSSPPARDAOC3APPALDH1A1 | |
| SCHEMBL7225415 | 0.77 | LSS (0.51) | LSSPPARDPOLBRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1091937-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000473-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2000-01-06 | — | — | WO | disclosed |