Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569074 | 0.86 | PPARA (0.48) | PPARAPPARGACHEMTNR1AMTNR1B | |
| SCHEMBL22703735 | 0.83 | PPARA (0.61) | PPARAPPARGPTGIRCYP2D6 | |
| SCHEMBL16900521 | 0.81 | PPARA (0.49) | PPARAPPARGACHEMTNR1AMTNR1B | |
| SCHEMBL9122812 | 0.80 | LMNA (0.55) | PPARAPPARG | |
| SCHEMBL14640150 | 0.80 | TAAR1 (0.54) | PPARAPPARGACHETAAR1CYP2D6 | |
| SCHEMBL19501290 | 0.80 | SMN1; SMN2 (0.55) | PPARAPPARG | |
| SCHEMBL2208586 | 0.79 | PPARG (0.47) | PPARAPPARGACHETAAR1CYP2D6 | |
| SCHEMBL29818702 | 0.79 | PPARG (0.47) | PPARAPPARGACHETAAR1CYP2D6 | |
| SCHEMBL6298211 | 0.79 | LMNA (0.61) | MTNR1AMTNR1B | |
| SCHEMBL19501291 | 0.78 | PPARA (0.48) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |