Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376454 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2HTTL3MBTL1COMTALDH1A1 | |
| SCHEMBL18685172 | 0.79 | RECQL (0.37) | SMN1; SMN2HTTL3MBTL1COMTALDH1A1 | |
| SCHEMBL116289 | 0.78 | — | — | |
| SCHEMBL26754743 | 0.78 | L3MBTL1 (0.41) | SMN1; SMN2HTTL3MBTL1COMTALDH1A1 | |
| SCHEMBL24937059 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2HTTL3MBTL1COMTALDH1A1 | |
| SCHEMBL26829349 | 0.77 | PIK3CG (0.33) | SMN1; SMN2 | |
| SCHEMBL26828264 | 0.77 | LRRK2 (0.37) | MAP3K5GAA | |
| SCHEMBL24828475 | 0.75 | L3MBTL1 (0.36) | SMN1; SMN2HTTL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL24007205 | 0.75 | L3MBTL1 (0.39) | SMN1; SMN2HTTL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL20642494 | 0.75 | MAP3K5 (0.34) | SMN1; SMN2HTTALDH1A1NPC1MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217879-A1 | PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |
| US-20230019732-A1 | EGFR INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019732-A1 | EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | SMN1; SMN2 4572/4885HTT 4716/4885L3MBTL1 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.