Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24353219 | 0.90 | EGFR (0.55) | EGFRKDRGAKHDAC3HDAC1 | |
| SCHEMBL20614661 | 0.82 | SRC (0.41) | EGFRKDRGAK | |
| SCHEMBL20614884 | 0.82 | SRC (0.41) | EGFRKDRGAKFLT1 | |
| SCHEMBL20673109 | 0.79 | EGFR (0.49) | EGFRKDRGAKKDM1AILK | |
| SCHEMBL22338293 | 0.77 | SRC (0.56) | EGFRKDRHDAC3HDAC1HDAC6 | |
| SCHEMBL20673100 | 0.77 | EGFR (0.46) | EGFRKDRGAKKDM1AILK | |
| SCHEMBL18387506 | 0.74 | EGFR (0.46) | EGFR | |
| SCHEMBL28011751 | 0.71 | EGFR (0.54) | EGFRKDRGAKHDAC3HDAC1 | |
| SCHEMBL19121105 | 0.70 | EGFR (0.42) | EGFR | |
| SCHEMBL27941737 | 0.69 | EGFR (0.61) | EGFRKDRGAKKDM1AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4119552-A1 | REGULATING CHIMERIC ANTIGEN RECEPTORS | Dana-Farber Cancer Institute, Inc. (US) | 2023-01-18 | — | — | EP | disclosed |