Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333145 | 0.79 | METAP2 (0.58) | MKNK1MKNK2METAP2ADORA2AADORA1 | |
| SCHEMBL1333147 | 0.79 | METAP2 (0.58) | MKNK1MKNK2METAP2ADORA2AADORA1 | |
| SCHEMBL12125329 | 0.76 | METAP2 (0.58) | MKNK1MKNK2METAP2ADORA2AADORA1 | |
| SCHEMBL21856026 | 0.68 | CUL4A (0.44) | MKNK1MKNK2ADORA2AADORA1ADORA3 | |
| SCHEMBL21856024 | 0.68 | CUL4A (0.44) | MKNK1MKNK2ADORA2AADORA1ADORA3 | |
| SCHEMBL30218990 | 0.68 | CUL4A (0.44) | MKNK1MKNK2ADORA2AADORA1ADORA3 | |
| SCHEMBL12125338 | 0.66 | METAP2 (0.58) | METAP2 | |
| SCHEMBL3783590 | 0.66 | METAP2 (0.49) | MKNK1MKNK2METAP2ADORA2AADORA1 | |
| SCHEMBL3783586 | 0.66 | METAP2 (0.49) | MKNK1MKNK2METAP2ADORA2AADORA1 | |
| SCHEMBL3807735 | 0.65 | MKNK1 (0.42) | MKNK1MKNK2ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379558-A1 | NOVEL HETEROCYCLIC COMPOUNDS FOR USE AS METAP-2 INHIBITORS | Merck Patent GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010083870-A1 | NOVEL HETEROCYCLIC COMPOUNDS FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-07-29 | — | — | WO | disclosed |