SCHEMBL2493892

SCHEMBL2493892

O=C1CC([N+](=O)[O-])C(=O)N1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAP3K14 Q99558 1/20 0.44
CRBN Q96SW2 2/20 0.37
CYP19A1 P11511 1/20 0.34
IDO1 P14902 1/20 0.31
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
MEN1 O00255 1/20 0.30
APEX1 P27695 1/20 0.30
KMT2A Q03164 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valeric Acid SCHEMBL28242517 0.78 LMNA (0.39) LMNAMEN1KMT2ATDP1
SCHEMBL16167221 0.71 MEN1 (0.30) MEN1KMT2A
SCHEMBL9542690 0.69 CREBBP (0.47) MAPTMEN1KMT2A
SCHEMBL11702833 0.69
SCHEMBL11702847 0.69
SCHEMBL23754724 0.67 MAP3K14 (0.36) MAP3K14CRBNCYP19A1LMNAMAPT
SCHEMBL2039535 0.64
SCHEMBL6897659 0.64
SCHEMBL28727342 0.62
SCHEMBL1024468 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379501-B1 METHOD FOR PREPARING ACTIVATED ESTERS SANOFI SA (FR) 2014-01-22 EP disclosed
CN-102292318-B Method for preparing activated esters SANOFI SA 2014-01-01 CN disclosed
US-8314244-B2 Method for preparing activated esters SANOFI (FR) 2012-11-20 US disclosed
US-20110313168-A1 METHOD FOR PREPARING ACTIVATED ESTERS SANOFI (FR) 2011-12-22 US disclosed
EP-2379501-A1 METHOD FOR PREPARING ACTIVATED ESTERS SANOFI (FR) 2011-10-26 EP disclosed
WO-2010076474-A1 METHOD FOR PREPARING ACTIVATED ESTERS SANOFI-AVENTIS (FR) 2010-07-08 WO disclosed
US-5552541-A Haptenic probes for detecting capture polynucleotides BECKMAN INSTRUMENTS, INC. (US) 1996-09-03 US disclosed
EP-0487718-A1 NUCLEIC ACID PROBES with negatively charged haptens which are attached to the probe via a hydrazine binding moiety BECKMAN INSTRUMENTS, INC. (US) 1992-06-03 EP disclosed
WO-1991019729-A1 NUCLEIC ACID PROBES AND PROTEIN PROBES BECKMAN INSTRUMENTS, INC. (US) 1991-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110313168-A1 METHOD FOR PREPARING ACTIVATED ESTERS C9, C1S, ALK MAP3K14 1772/4885CRBN 2950/4885CYP19A1 863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.