Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | FLT3 | P36888 | 8/20 | 0.52 |
| ▸ | EML4 | Q9HC35 | 8/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.52 |
| ▸ | ROS1 | P08922 | 6/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | BUB1 | O43683 | 1/20 | 0.49 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205561 | 1.00 | ALK (0.52) | ALKFLT3EML4RETROS1 | |
| SCHEMBL29173341 | 0.94 | ALK (0.44) | ALKFLT3EML4RETROS1 | |
| SCHEMBL30206110 | 0.94 | ALK (0.44) | ALKFLT3EML4RETROS1 | |
| SCHEMBL30205536 | 0.91 | SYK (0.46) | ALKFLT3EML4RETROS1 | |
| SCHEMBL24943800 | 0.91 | SYK (0.46) | ALKFLT3EML4RETROS1 | |
| SCHEMBL24944157 | 0.91 | EML4 (0.47) | ALKFLT3EML4RETROS1 | |
| SCHEMBL30205760 | 0.91 | EML4 (0.47) | ALKFLT3EML4RETROS1 | |
| SCHEMBL24944171 | 0.89 | FLT3 (0.40) | ALKFLT3EML4RETROS1 | |
| SCHEMBL24944177 | 0.89 | FLT3 (0.42) | ALKFLT3EML4RETROS1 | |
| SCHEMBL30205556 | 0.89 | FLT3 (0.42) | ALKFLT3EML4RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |