Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944753 | 1.00 | LRRK2 (0.37) | LRRK2FPR2RIPK1MTORALK | |
| SCHEMBL30205484 | 1.00 | LRRK2 (0.37) | LRRK2FPR2RIPK1MTORALK | |
| SCHEMBL30206116 | 0.93 | LRRK2 (0.39) | LRRK2FPR2RIPK1MTORALK | |
| SCHEMBL30206231 | 0.90 | LRRK2 (0.35) | LRRK2FPR2MTORSYK | |
| SCHEMBL24944379 | 0.90 | LRRK2 (0.35) | LRRK2FPR2MTORSYK | |
| SCHEMBL24944380 | 0.90 | LRRK2 (0.35) | LRRK2FPR2MTORSYK | |
| SCHEMBL24944958 | 0.89 | ATM (0.36) | LRRK2ALKATMEML4SYK | |
| SCHEMBL24943820 | 0.89 | ATM (0.36) | LRRK2ALKATMEML4SYK | |
| SCHEMBL24944962 | 0.89 | ATM (0.36) | LRRK2ALKATMEML4SYK | |
| SCHEMBL24944439 | 0.88 | FPR2 (0.35) | LRRK2FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |