Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | EML4 | Q9HC35 | 10/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 5/20 | 0.32 |
| ▸ | ROS1 | P08922 | 5/20 | 0.32 |
| ▸ | FLT3 | P36888 | 5/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205545 | 1.00 | LRRK2 (0.34) | LRRK2SYKEML4ALKTTK | |
| SCHEMBL29173677 | 0.93 | TTK (0.34) | LRRK2SYKTTKZAP70 | |
| SCHEMBL30206137 | 0.93 | TTK (0.34) | LRRK2SYKTTKZAP70 | |
| SCHEMBL30205483 | 0.90 | EML4 (0.36) | SYKEML4ALKRETROS1 | |
| SCHEMBL24944436 | 0.90 | EML4 (0.36) | SYKEML4ALKRETROS1 | |
| SCHEMBL24944748 | 0.85 | MTOR (0.41) | SYKEML4ALKRETROS1 | |
| SCHEMBL24944438 | 0.85 | MTOR (0.41) | SYKEML4ALKRETROS1 | |
| SCHEMBL30205534 | 0.85 | MTOR (0.41) | SYKEML4ALKRETROS1 | |
| SCHEMBL30205512 | 0.85 | MTOR (0.41) | SYKEML4ALKRETROS1 | |
| SCHEMBL24944983 | 0.85 | PI4KB (0.34) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |