Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 13/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.39 |
| ▸ | RET | P07949 | 12/20 | 0.39 |
| ▸ | ROS1 | P08922 | 12/20 | 0.39 |
| ▸ | FLT3 | P36888 | 12/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944774 | 1.00 | EML4 (0.39) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944775 | 1.00 | EML4 (0.39) | EML4ALKRETROS1FLT3 | |
| Formic Acid SCHEMBL30205516 | 0.97 | RET (0.37) | EML4ALKRETROS1FLT3 | |
| Formic Acid SCHEMBL29173298 | 0.97 | RET (0.37) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30206082 | 0.92 | RET (0.40) | EML4ALKRETROS1FLT3 | |
| SCHEMBL24944196 | 0.92 | RET (0.40) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205975 | 0.92 | BTK (0.32) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29173379 | 0.92 | BTK (0.32) | EML4ALKRETROS1FLT3 | |
| Formic Acid SCHEMBL29173316 | 0.90 | RET (0.38) | EML4ALKRETROS1FLT3 | |
| Formic Acid SCHEMBL30205567 | 0.90 | RET (0.38) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |