Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205960 | 1.00 | LRRK2 (0.34) | LRRK2TLR7FPR2KRASCCNC | |
| SCHEMBL30206270 | 0.94 | LRRK2 (0.36) | LRRK2TLR7KRASCCNCCDK8 | |
| SCHEMBL24944495 | 0.89 | TLR7 (0.37) | LRRK2TLR7FPR2CCNCCDK8 | |
| SCHEMBL30206258 | 0.89 | TLR7 (0.37) | LRRK2TLR7FPR2CCNCCDK8 | |
| SCHEMBL30205936 | 0.89 | TLR7 (0.37) | LRRK2TLR7FPR2CCNCCDK8 | |
| SCHEMBL24944493 | 0.89 | TLR7 (0.37) | LRRK2TLR7FPR2CCNCCDK8 | |
| SCHEMBL24944781 | 0.89 | TLR7 (0.37) | LRRK2TLR7FPR2CCNCCDK8 | |
| SCHEMBL24944380 | 0.88 | LRRK2 (0.35) | LRRK2FPR2 | |
| SCHEMBL24944379 | 0.88 | LRRK2 (0.35) | LRRK2FPR2 | |
| SCHEMBL30206231 | 0.88 | LRRK2 (0.35) | LRRK2FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |