Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 3/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 2/20 | 0.30 |
| ▸ | GSK3B | P49841 | 2/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206258 | 1.00 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30205936 | 1.00 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944781 | 1.00 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944495 | 1.00 | TLR7 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL31577349 | 0.94 | TLR7 (0.36) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30206282 | 0.94 | LRRK2 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL30206277 | 0.94 | LRRK2 (0.37) | TLR7LRRK2CCNCCDK8BRAF | |
| SCHEMBL24944780 | 0.89 | LRRK2 (0.34) | TLR7LRRK2CCNCCDK8FPR2 | |
| SCHEMBL30205960 | 0.89 | LRRK2 (0.34) | TLR7LRRK2CCNCCDK8FPR2 | |
| SCHEMBL24944753 | 0.88 | LRRK2 (0.37) | LRRK2FPR2ABCB11NQO2MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |