Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205690 | 1.00 | LRRK2 (0.42) | LRRK2TRPV4MAP3K14JAK2JAK1 | |
| SCHEMBL24944605 | 0.93 | LRRK2 (0.37) | LRRK2PDE10AIGF1RCDK2SYK | |
| SCHEMBL30206008 | 0.93 | LRRK2 (0.37) | LRRK2PDE10AIGF1RCDK2SYK | |
| SCHEMBL30206393 | 0.92 | LRRK2 (0.41) | LRRK2TRPV4MAP3K14PDE10AIGF1R | |
| SCHEMBL30205603 | 0.88 | PDE10A (0.36) | LRRK2JAK1PDE10ASYK | |
| SCHEMBL24943842 | 0.88 | PDE10A (0.36) | LRRK2JAK1PDE10ASYK | |
| SCHEMBL24944966 | 0.87 | LRRK2 (0.46) | LRRK2MAP3K14JAK2JAK1TYK2 | |
| SCHEMBL30205514 | 0.87 | LRRK2 (0.46) | LRRK2MAP3K14JAK2JAK1TYK2 | |
| SCHEMBL29173285 | 0.83 | SYK (0.32) | LRRK2PDE10ASYK | |
| SCHEMBL24944555 | 0.83 | LRRK2 (0.41) | LRRK2PDE10ACDK2SYKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |