Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205514 | 1.00 | LRRK2 (0.46) | LRRK2IRAK4IRAK1JAK1JAK2 | |
| SCHEMBL24944606 | 0.93 | LRRK2 (0.38) | LRRK2IRAK4IGF1RCDK2KCNH2 | |
| SCHEMBL30206291 | 0.93 | LRRK2 (0.38) | LRRK2IRAK4IGF1RCDK2KCNH2 | |
| SCHEMBL30206224 | 0.92 | LRRK2 (0.45) | LRRK2IRAK4MAP3K14IGF1RCDK2 | |
| SCHEMBL30205777 | 0.89 | LRRK2 (0.36) | LRRK2IRAK4JAK1JAK2 | |
| SCHEMBL24944797 | 0.89 | LRRK2 (0.36) | LRRK2IRAK4JAK1JAK2 | |
| SCHEMBL24944965 | 0.87 | LRRK2 (0.42) | LRRK2JAK1JAK2TYK2JAK3 | |
| SCHEMBL30205690 | 0.87 | LRRK2 (0.42) | LRRK2JAK1JAK2TYK2JAK3 | |
| SCHEMBL29173317 | 0.83 | LRRK2 (0.38) | LRRK2 | |
| SCHEMBL24944216 | 0.82 | LRRK2 (0.38) | LRRK2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |