Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24945738 | 0.93 | GPR119 (0.52) | GPR119PRKAA2CHRM2CHRM1CCR1 | |
| SCHEMBL24945784 | 0.92 | GPR119 (0.51) | GPR119CHRM2CHRM1CHRM4 | |
| SCHEMBL23744134 | 0.88 | GPR119 (0.55) | GPR119CHRM2CHRM1CHRM4 | |
| SCHEMBL31492280 | 0.88 | GPR119 (0.49) | GPR119PRKAA2CHRM2CHRM1CCR1 | |
| SCHEMBL23744180 | 0.87 | CHRM2 (0.57) | GPR119PRKAA2CHRM2CHRM1CHRM4 | |
| SCHEMBL23744603 | 0.86 | CHRM2 (0.55) | PRKAA2CHRM2CHRM1PRKAB2PRKAG1 | |
| SCHEMBL23744619 | 0.86 | CHRM4 (0.53) | CHRM2CHRM1CHRM4 | |
| SCHEMBL24945628 | 0.84 | GPR119 (0.44) | GPR119CHRM2CHRM1CHRM4 | |
| SCHEMBL24945611 | 0.84 | GPR119 (0.42) | GPR119CHRM2CHRM1CHRM4 | |
| SCHEMBL24945613 | 0.84 | HTR2A (0.45) | GPR119CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010078-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2023-02-02 | — | — | WO | disclosed |