Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488711 | 1.00 | PIK3CD (0.36) | PIK3CDKMT2AALDH1A1MEN1HRH3 | |
| SCHEMBL3694790 | 0.75 | CYP3A4 (0.43) | PIK3CDKMT2AALDH1A1MEN1CYP2D6 | |
| SCHEMBL3694792 | 0.75 | CYP3A4 (0.43) | PIK3CDKMT2AALDH1A1MEN1CYP2D6 | |
| SCHEMBL14155738 | 0.71 | SMN1; SMN2 (0.55) | PIK3CDKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4667620 | 0.71 | SMN1; SMN2 (0.55) | PIK3CDKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14155739 | 0.71 | SMN1; SMN2 (0.55) | PIK3CDKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3963916 | 0.71 | ATM (0.53) | KMT2AMEN1CYP2D6ATM | |
| SCHEMBL3962581 | 0.71 | ATM (0.53) | KMT2AMEN1CYP2D6ATM | |
| SCHEMBL2494717 | 0.71 | ATM (0.53) | KMT2AMEN1CYP2D6ATM | |
| SCHEMBL2488710 | 0.71 | ATM (0.53) | KMT2AMEN1CYP2D6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379554-A1 | NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2011-10-26 | — | — | EP | disclosed |
| EP-2238135-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2010081874-A1 | NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |
| WO-2009090222-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |