Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14155738 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2ABCHEPIK3CDGAA | |
| SCHEMBL14155739 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2ABCHEPIK3CDGAA | |
| SCHEMBL30006184 | 0.90 | KMT2A (0.64) | SMN1; SMN2KMT2ABCHEPIK3CDGAA | |
| SCHEMBL4732168 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2APIK3CDGAAALDH1A1 | |
| SCHEMBL14314285 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ABCHEGAAALDH1A1 | |
| SCHEMBL16941603 | 0.85 | PIK3CD (0.44) | SMN1; SMN2KMT2ABCHEPIK3CDGAA | |
| SCHEMBL12443041 | 0.84 | POLB (0.47) | SMN1; SMN2KMT2APIK3CDALDH1A1KDM4E | |
| SCHEMBL25664009 | 0.84 | PIK3CD (0.47) | SMN1; SMN2KMT2APIK3CDALDH1A1KDM4E | |
| SCHEMBL25664000 | 0.84 | PIK3CD (0.47) | SMN1; SMN2KMT2APIK3CDALDH1A1KDM4E | |
| SCHEMBL25663999 | 0.84 | PIK3CD (0.47) | SMN1; SMN2KMT2APIK3CDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638933-B1 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2008-06-11 | — | — | EP | claimed |
| EP-1427408-A4 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$g(a) CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2005-10-26 | — | — | EP | claimed |
| EP-1427408-A2 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$g(a) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-16 | — | — | EP | claimed |
| WO-2003024899-A2 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-27 | — | — | WO | claimed |