Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202614 | 1.00 | MAPT (0.47) | MAPTALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL24951142 | 0.92 | NPC1 (0.44) | MAPTALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL30202821 | 0.92 | NPC1 (0.44) | MAPTALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL30202836 | 0.88 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL24951699 | 0.88 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL24951623 | 0.82 | JAK3 (0.50) | ALDH1A1KDM4EHSD17B10BTKJAK2 | |
| SCHEMBL30202785 | 0.82 | JAK3 (0.50) | ALDH1A1KDM4EHSD17B10BTKJAK2 | |
| SCHEMBL20558425 | 0.80 | BTK (0.46) | MAPTKDM4EHSD17B10MAPK14LMNA | |
| SCHEMBL30202669 | 0.79 | TP53 (0.37) | MAPTMAPK14BTKTP53 | |
| SCHEMBL30203025 | 0.78 | JAK1 (0.37) | ALDH1A1KDM4EHSD17B10BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |