Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20463047 | 0.84 | TTR (0.64) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL15828247 | 0.84 | TTR (0.71) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL20145409 | 0.80 | TTR (0.69) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21618544 | 0.80 | TTR (0.62) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL24953188 | 0.80 | TTR (0.83) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| Acoramidis SCHEMBL15816954 | 0.80 | TTR (1.00) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| Acoramidis SCHEMBL20475239 | 0.79 | TTR (0.98) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL15816998 | 0.79 | TTR (0.81) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL15158388 | 0.78 | TTR (1.00) | TTRALBHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL25129906 | 0.78 | TTR (0.62) | TTRALBHSD17B10SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009612-A1 | ACORAMIDIS (3-(3-(3,5-DIMETHYL-1H-PYRAZOL-4-YL)PROPOXY)-4-FLUOROBENZOIC ACID) DERIVATIVES FOR STABILIZING TRANSTHYRETIN (TTS) AND INHIBITING TTS MISFOLDING FOR THE TREATMENT OF E.G. PERIPHERAL TTR AMYLOIDOSIS | PROTEGO BIOPHARMA, INC. (US) | 2023-02-02 | — | — | WO | disclosed |