Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828247 | 0.96 | TTR (0.71) | TTRALBHSD17B10LMNAHTT | |
| SCHEMBL15832081 | 0.84 | TTR (0.95) | TTRALBHSD17B10LMNAHTT | |
| SCHEMBL17522783 | 0.83 | TTR (0.81) | TTRALBHSD17B10LMNAHTT | |
| Acoramidis SCHEMBL15816954 | 0.82 | TTR (1.00) | TTRALBHSD17B10LMNAHTT | |
| Acoramidis SCHEMBL29350324 | 0.82 | TTR (1.00) | TTRALBHSD17B10LMNAHTT | |
| SCHEMBL17522791 | 0.81 | TTR (0.94) | TTRALBHSD17B10LMNAHTT | |
| Acoramidis SCHEMBL29390976 | 0.81 | TTR (0.98) | TTRALBHSD17B10LMNAHTT | |
| Acoramidis SCHEMBL20475239 | 0.81 | TTR (0.98) | TTRALBHSD17B10LMNAHTT | |
| SCHEMBL24953182 | 0.80 | TTR (0.67) | TTRALBHSD17B10LMNAHTT | |
| SCHEMBL15158388 | 0.80 | TTR (1.00) | TTRALBHSD17B10LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934514-B1 | TRANSTHYRETIN STABILIZERS AND THEIR USE FOR INHIBITING TRANSTHYRETIN AMYLOIDOSIS AND PROTEIN-PROTEIN INTERACTIONS | UNIV LELAND STANFORD JUNIOR (US) | 2018-05-16 | — | — | EP | disclosed |