Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954369 | 0.94 | MAP4K1 (0.67) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL30893059 | 0.94 | MAP4K1 (0.67) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24954322 | 0.92 | MAP4K1 (0.71) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24954323 | 0.92 | MAP4K1 (0.71) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL30215941 | 0.90 | MAP4K1 (0.62) | MAP4K1TNIKAXLMERTKJAK2 | |
| SCHEMBL24955669 | 0.90 | MAP4K1 (0.62) | MAP4K1TNIKAXLMERTKJAK2 | |
| SCHEMBL24954501 | 0.88 | MAP4K1 (0.51) | MAP4K1TNIKMAP3K11ABL1 | |
| SCHEMBL24955691 | 0.85 | MAP4K1 (0.66) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL30893068 | 0.85 | MAP4K1 (0.66) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL22858921 | 0.85 | MAP4K1 (0.69) | MAP4K1TNIKAXLMERTKMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |