Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 5/20 | 0.35 |
| ▸ | TYK2 | P29597 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954369 | 1.00 | MAP4K1 (0.67) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24954367 | 0.94 | MAP4K1 (0.58) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL30893068 | 0.91 | MAP4K1 (0.66) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24955691 | 0.91 | MAP4K1 (0.66) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24954370 | 0.90 | MAP4K1 (0.72) | MAP4K1TNIKJAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL30215931 | 0.90 | MAP4K1 (0.71) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL24954358 | 0.88 | MAP4K1 (0.73) | MAP4K1TNIKJAK2JAK1TYK2 | |
| SCHEMBL30893063 | 0.88 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954299 | 0.88 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL30215947 | 0.88 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |