SCHEMBL2495557

SCHEMBL2495557

O=C1OC(=O)[C@@H]2C[C@H]12

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14685237 1.00 KDM4E (0.39)
SCHEMBL4359852 1.00
SCHEMBL615001 1.00 KDM4E (0.39)
SCHEMBL14669163 1.00
SCHEMBL13444708 1.00 KDM4E (0.39)
SCHEMBL24843176 1.00 KDM4E (0.39)
SCHEMBL16360071 1.00 KDM4E (0.39)
SCHEMBL14424191 1.00 KDM4E (0.39)
SCHEMBL15498544 1.00 KDM4E (0.39)
SCHEMBL22300612 0.91 KDM4E (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4178620-B1 PLASMA KALLIKREIN INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-01 EP disclosed
EP-4712965-A2 BENZIMIDAZOLE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD Springworks Therapeutics, Inc. (US) 2026-03-25 EP disclosed
US-12528786-B2 Plasma kallikrein inhibitors MERCK SHARP & DOHME LLC (US) 2026-01-20 US disclosed
EP-4143195-B1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2025-05-21 EP disclosed
WO-2024238738-A2 BENZIMIDAZOLE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed
US-20240383891-A1 BENZIMIDAZOLE AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD CISTIM LEUVEN VZW (BE) 2024-11-21 US disclosed
US-12024524-B2 Imidazopyridazines as modulators of IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-07-02 US disclosed
US-20230357347-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS CARMOT THERAPEUTICS, INC. 2023-11-09 US disclosed
US-20230357347-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS CARMOT THERAPEUTICS, INC. 2023-11-09 US disclosed
US-20230357254-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2023-11-09 US disclosed
US-4859680-A Pyrimidine derivatives as antiviral compounds MERCK & CO., INC. (US) 1989-08-22 US disclosed
US-4642315-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1987-02-10 US disclosed
US-4617304-A VIRICIDE; HERPES MERCK & CO., INC. (US) 1986-10-14 US disclosed
US-4587234-A HYPOTENSIVES E. R. SQUIBB & SONS, INC. (US) 1986-05-06 US disclosed
EP-0159264-A2 Antiviral compounds MERCK & CO. INC. (US) 1985-10-23 EP disclosed
US-4499079-A ENZYME INHIBITORS, HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1985-02-12 US disclosed
EP-0007128-B1 DERIVATIVES OF 3-AZABICYCLO(3.1.0)HEXANE AND PROCESSES FOR THEIR PREPARATION SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1983-02-16 EP disclosed
EP-0007128-A1 Derivatives of 3-azabicyclo(3.1.0)hexane and processes for their preparation SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1980-01-23 EP disclosed
US-4183857-A 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione SHELL OIL COMPANY (US) 1980-01-15 US disclosed
US-3956386-A Cis-N,N,N',N'-tetramethylcyclopropane-1,2-dicarboxamide and use thereof MONSANTO COMPANY (US) 1976-05-11 US disclosed