SCHEMBL24955656

SCHEMBL24955656

Cn1ncc2c(N3C[C@H]4COC[C@H]4C3)nc(C#Cc3nc(-c4ccccc4)cn3COCC[Si](C)(C)C)nc21

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 4/20 0.38
KLKB1 P03952 1/20 0.31
PIK3CA P42336 1/20 0.31
MTOR P42345 1/20 0.31
BCDIN3D Q7Z5W3 1/20 0.30
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24955663 0.91 DGAT1 (0.37) DGAT1KLKB1PIK3CAMTOR
SCHEMBL24955657 0.91 DGAT1 (0.35) DGAT1KLKB1PIK3CAMTOR
SCHEMBL24955659 0.89 DGAT1 (0.38) DGAT1PIK3CAMTOR
SCHEMBL24955552 0.88 MTOR (0.33) DGAT1MTOR
SCHEMBL31106972 0.85 DGAT1 (0.38) DGAT1KLKB1
SCHEMBL24955726 0.85 DGAT1 (0.38) DGAT1KLKB1
SCHEMBL30202075 0.84 PDE10A (0.37) PIK3CAMTORBCDIN3DPDE10A
SCHEMBL24955728 0.80 DGAT1 (0.34) DGAT1PIK3CAMTOR
SCHEMBL31106965 0.80 DGAT1 (0.34) DGAT1PIK3CAMTOR
SCHEMBL24956793 0.77 MTOR (0.41) PIK3CAMTORPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023007185-A1 IMIDAZOLE ORGANIC COMPOUNDS AND THEIR USE AGAINST INFLAMMATORY BOWEL DISEASE Benevolentai Cambridge Limited (GB) 2023-02-02 WO disclosed