Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25575154 | 0.92 | ALDH1A1 (0.49) | ALDH1A1TDP1L3MBTL1GAACYP1A2 | |
| SCHEMBL14026543 | 0.87 | PTGDR2 (0.45) | ALDH1A1TDP1L3MBTL1PTGDR2CYP1A2 | |
| SCHEMBL14026553 | 0.86 | NPC1 (0.50) | ALDH1A1TDP1L3MBTL1GAAPTGDR2 | |
| SCHEMBL4574442 | 0.86 | NPC1 (0.56) | ALDH1A1TDP1GAAPTGDR2CYP1A2 | |
| SCHEMBL15074081 | 0.84 | POLB (0.48) | ALDH1A1L3MBTL1GAAPTGDR2CYP1A2 | |
| SCHEMBL13247320 | 0.83 | TDP1 (0.49) | ALDH1A1TDP1L3MBTL1GAAHSD17B10 | |
| SCHEMBL14045982 | 0.83 | MRGPRX4 (0.46) | ALDH1A1TDP1PTGDR2KDM4EMEN1 | |
| SCHEMBL6213275 | 0.83 | NPC1 (0.47) | PTGDR2CYP1A2CYP2C9HIF1AHSD17B10 | |
| SCHEMBL13946935 | 0.82 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1GAACYP1A2CYP2C9 | |
| SCHEMBL4595546 | 0.81 | PTGDR2 (0.68) | TDP1PTGDR2CYP2C9HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040549-B1 | BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-23 | — | — | EP | disclosed |
| US-8030321-B2 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2011-10-04 | — | — | US | disclosed |
| US-20090325927-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | CHAVEZ FRANK | 2009-12-31 | — | — | US | disclosed |
| US-7576092-B2 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-08-18 | — | — | US | disclosed |
| EP-2040549-A2 | BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-01 | — | — | EP | disclosed |
| US-20080269239-A1 | Pyrimidine Compounds as Histamine Modulators | ARGENTA DISCOVERY LTD. (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20080015200-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
| WO-2008008359-A2 | BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | WO | disclosed |
| EP-1776982-A1 | Pyrimidine compounds as histamine modulators | Argenta Discovery Limited (GB) | 2007-04-25 | — | — | EP | disclosed |
| EP-1767537-A1 | Pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269239-A1 | Pyrimidine Compounds as Histamine Modulators | HRH4, HRH3, HRH2 | ALDH1A1 2638/4885TDP1 1569/4885L3MBTL1 3833/4885 |
| US-20080015200-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | HRH4, HRH1, HRH2 | ALDH1A1 2682/4885TDP1 3175/4885L3MBTL1 3018/4885 |
| US-20090325927-A1 | Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor | HRH4, HRH1, HRH2 | ALDH1A1 2682/4885TDP1 3175/4885L3MBTL1 3018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.