Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24955735 | 1.00 | MAP4K1 (0.63) | MAP4K1PIK3CGMAP3K11TNIKCAMKK2 | |
| SCHEMBL24954376 | 0.91 | MAP4K1 (0.59) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL24954375 | 0.91 | MAP4K1 (0.59) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL30215945 | 0.91 | MAP4K1 (0.55) | MAP4K1PIK3CGMAP3K11TNIKCAMKK2 | |
| SCHEMBL24954318 | 0.91 | MAP4K1 (0.55) | MAP4K1PIK3CGMAP3K11TNIKCAMKK2 | |
| SCHEMBL24954508 | 0.89 | MAP4K1 (0.76) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL24954305 | 0.85 | MAP4K1 (0.53) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL24955654 | 0.85 | MAP4K1 (0.53) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL30215946 | 0.85 | MAP4K1 (0.53) | MAP4K1PIK3CGMAP3K11TNIK | |
| SCHEMBL24954490 | 0.83 | MAP4K1 (0.63) | MAP4K1PIK3CGMAP3K11CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |